Internal clock that measures aging discovered in DNA
The internal mechanism shows that different parts of our body age
faster or slower, according to a study published in the Genome Biology
journal on Monday.
The “epigenetic clock," discovered by UCLA professor of human genetics Steve Horvath and his team, has revealed that the age of diseased tissues are much older than healthy tissues in the body.
It found that women’s breast tissue ages faster than other tissues, which could explain why breast cancer is very common among women. It was discovered that cancerous breast tissue is on average 36 years older than other tissue.
Horvath also developed the DNA Methylation Age Calculator, a software program that predicts the DNAm age of tissue.
As part of his research, Horvath studied nearly 8,000 samples of 51 different healthy and cancerous cells and tissues. He used methylation, a process that chemically modifies DNA and causes it to change over time.
Based on the changes that were observed in those tissues, the scientist was able to identify 353 DNA markers from 51 cell types that change as people age. This could be used as a biological clock, spinning faster in the years up to around age 20, then slowing down.
Though the study is preliminary, it may be used in the future as an anti-aging tool.
“In the same way our circadian clocks keep track of hours, this new epigenetic clock keeps track of years,” said Horvath, as quoted by Forbes. “Can it be used as an anti-aging tool? That’s an exciting question we need to answer.”
The study also shows that the biological clock was reset to zero when cells were plucked from an adult and reprogrammed back to a stem-cell-like state.
"It provides a proof of concept that one can reset the clock," noted Horvath.
The process for converting adult cells into stem cells which can grow into any tissue won the Nobel Prize in 2012. The method was discovered by Cambridge University’s Sir John Gurdon and Kyoto University’s Shinya Yamanaka.