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28 May, 2021 22:08

‘Proof we’re on right track’: Russian drug developer 'delighted' about ‘similar’ Aussie Covid-19 therapy, but says Russia 'ahead'

‘Proof we’re on right track’: Russian drug developer 'delighted' about ‘similar’ Aussie Covid-19 therapy, but says Russia 'ahead'

A team of scientists from Australia and the US has announced the development of an “experimental” Covid-19 treatment. Russia embarked on the same path months earlier, with a drug now undergoing phase-two trials, RT has learned.

“We were delighted to know that another very strong team of scientists from Australia and the US have developed a similar drug,” Musa Khaitov, the head of the Immunology Institute of the Russian Federal Medical and Biological Agency (FMBA), said on Friday, commenting on a recent announcement by the Australian researchers.

Earlier in May, a research group from the Menzies Health Institute Queensland (MHIQ) at Griffith University, working with American specialists from the City of Hope National Medical Center, said it had “developed an experimental direct-acting antiviral therapy to treat Covid-19.”

The team said it had created a “next-generation antiviral approach,” allowing their drug to directly attack the virus’ ribonucleic acid (RNA) and stopping it from replication. “Treatment with virus-specific siRNA [small interfering RNA] reduces viral load by 99.9%. These stealth nanoparticles can be delivered to a wide range of lung cells and silence viral genes,’’ said co-lead researcher Professor Nigel McMillan of MHIQ.

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Khaitov said his team at the FMBA Immunology Institute had been exploring the same approach based on viral RNA interference for quite some time, and had already registered a patent for a drug that “has specific… antiviral effect against Covid-19.”

“We knew this approach was explored throughout the world,” he said, adding that the research data published by the Australian and the US team “proves we are on the right track.”

The Russian team published its own research results in the ‘Allergy’ journal on March 15, and the Australian and the US scientists followed with their May 5 publication in the ‘Molecular Therapy’ journal.

“The Australians are going the same way,” Khaitov said, adding that he and his colleagues were “only glad” to hear such news. The MHIQ team only mentioned treatment results in mice, adding that the therapy applied to animals infected with Covid-19 “improved survival and loss of disease.”

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According to Khaitov, the Russian team is well beyond that stage in their trials. “Pre-clinical trials showed that our drug is safe and effective in the treatment of animals. It also successfully passed the first stage of the clinical trials, as it was proven that [the drug] is safe for healthy people,” the Immunology Institute head said.

The Russian researchers are now conducting phase two of their clinical trials on Covid-19 patients. According to Khaitov, some 400 volunteers are taking part in the trials, and he hopes to finish the tests by the end of the year.

“After that, we would be able to register the drug,” he said.

While similar in some ways, the Russian and Australian approaches differ in one important respect: drug delivery. The MHIQ team opted for an intravenous injection of certain lipid nanoparticles that are designed to deliver the drug to the lungs.

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Khaitov said that such an approach “raises some questions” that can only be resolved during clinical trials. He argues that the delivery mechanism chosen by his team “is safer and more advantageous.”

The FMBA Immunology Institute has created an aerosol that needs to be inhaled and then goes directly to the upper and lower airways as well as to the lungs. “The drug is delivered to the cells that are primarily affected by the coronavirus,” Khaitov explained. His team is now working on another form of the drug that can be used for preventive action against Covid-19.

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