UEFA Cup: all-Ukrainian semis loom
Mark Hughes's side went down 3-1, despite taking a 35-second lead in Germany.
The Manchester side now need a big performance at home next week to keep in the silverware hunt this season.
Werder Bremen have now been installed as frontrunners to lift the last ever UEFA Cup – before it becomes the Europa League. A brace from Diego steered the Germans to a 3-1 win over Udinese.
Elsewhere, this was not a bad night at all for the Ukrainian contingent in the tournament.
Dynamo Kiev made a draw away to PSG, while Shakhtar were 2-0 winners over another French side Marseille. The results make the all-Ukrainian semifinal more and more real.